![]() Oral treatment of B12 deficiency is not always effective, depending on the cause.By injection: 50 mcg/kg every 2 weeks (effective in one study).PLEASE NOTE: Always speak with your veterinarian before giving vitamins of any kind to your pet. Gel, intranasal: 500 mcg/0.1 mL in 5 mL bottlesĥ00 mcg and 1000 mcg tablets 100 mcg/mL injection (30ml vial) 1000 mcg/mL injection (10 and 30 mL vials).ĭosing Information of Vitamin B12 in Dogs and Cats Vitamin B12 is supplied in a variety of methods, including:ġ00 mcg, 250 mcg, 500 mcg, 1000 mcg, and 5000 mcg tablets A number of drugs are known to affect the absorption of vitamin B12, including neomycin, potassium chloride, p-aminosalicylic acid, and colchicine.Anaphylactic shock and death have been reported in humans following administration of vitamin B12 by injection. Vitamin B12 is essentially non-toxic but it should not be given to animals with known hypersensitivity to it or to cobalt.Treatment of primary or secondary B12 deficiency.Veterinary formulations: None (except as part of multivitamin formulations).Human formulations: Big Shot-12® (Naturally), Crystamine® (Dunhall), Cyanojet® (Mayrand), Cyomin® (Forest), Rubesol® (Central), Hydro-Crsyti-12® (Roberts Hauck), LA-12® (Hyrex), Nascobal® (Nastech), and generic Vitamin B12 (injectable and oral preparations).This vitamin is registered for use in humans.A congenital B12 malabsorption syndrome has been reported in giant schnauzers, border collies, beagles, and in cats.īrand Names and Other Names of Vitamin B12.Hematological signs include non-regenerative megaloblastic anemia, anisocytosis, poikilocytosis, and neutropenia with hypersegmentation, Biochemical signs of B12 deficiency include reduced serum cobalamin levels, increased serum methylmalonic acid levels, homocystinuria and methylmalonuria. Clinical signs of B12 deficiency include inappetance, lethargy, and failure to thrive.Tetrahydrofolate is involved in purine, pyrimidine, and nucleic acid biosynthesis. The most important reactions in the body in which B12 is involved are:Ī) rearrangement of methylmalonyl-CoA to succinyl-CoA for use in gluconeogenesis b) transfer of a methyl group from N5-methyl tetrahydrofolate to homocysteine in the formation of methionine with resultant formation of tetrahydrofolate.Also, since B12 is involved in the synthesis of lipid and protein components of myelin, demyelination and nerve degeneration will occur in severe B12 deficiency. Deficiency of B12 causes pernicious (megaloblastic) anemia by affecting DNA production. Frank deficiency of B12 or gastric, intestinal, or pancreatic disorders that affect the absorption of B12 will lead to B12 deficiency. The liver is a rich repository for B12 and releases it, as needed into the systemic blood stream. It is then transported to the liver in the bloodstream bound to transcobalamin-2 (TC-2). Free B12 then attaches to intrinsic factor (IF) to be transported across ileal cells as a dimer. Ingested B12 is bound to R-proteins and must be liberated by calcium, proteases, and bicarbonate in the duodenum before it can be absorbed. B12 is generally absent from plant and vegetable food sources, unless the food is contaminated by microbes. The cobalt-containing B12 molecule is the largest molecule to be transferred across the intestinal mucosa and transfer occurs only in the ileum.It is also essential for the maintenance of the integrity of the nervous system and for the synthesis of molecules involved in fatty acid biosynthesis, amino acid metabolism, and the production of energy. It works in close concert with folate in the synthesis of the building blocks for DNA and RNA synthesis.Vitamin B12 (cyanocobalamin and hydroxocobalamin) is essential to growth, cell reproduction, hematopoesis, and nucleoprotein, myelin synthesis, and treating B12 deficiency for dogs and cats.Overview of Using Vitamin B12 for Dogs and Cats
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